The structure of HLA-B27 reveals nonamer self-peptides bound in an extended conformation.
basic_science · Level V
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Abstract
X-ray crystallography reveals electron density in the antigen-binding site of HLA-B27 that is an interpretable image of nonameric peptides in a largely extended conformation. Clear density exists for the main chain and several side chains and is consistent with the sequence of 11 nonameric self-peptides eluted from HLA-B27. Pockets in the antigen-binding cleft bind four side chains and the amino and carboxyl termini of the peptide.
Medical subject headings
- HLA-B27 Antigen
- Oligopeptides