Absence of association of HTLV-I infection with type 1 neurofibromatosis in the United States or Japan.
case_series · Level IV
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Abstract
An HTLV-I tax transgenic mouse model develops a syndrome with similarities to type 1 neurofibromatosis (NF-1). To investigate possible associations between this human retrovirus and NF-1, we have analyzed 67 neurofibromas from Japan (where HTLV-I infection is endemic) and compared them with 21 cases from the United States. We were not able to identify virus in tumor tissue in either group. This suggests that HTLV-I infection is not commonly associated with NF-1.
Medical subject headings
- HTLV-I Infections
- Neurofibromatosis 1