Ultrasome: efficient aberration caller for copy number studies of ultra-high resolution.
Where this comes from
- Record sourced from PubMed, PMID 19228802.
- Also identified by DOI 10.1093/bioinformatics/btp091.
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Abstract
Multimillion-probe microarrays allow detection of gains and losses of chromosomal material at unprecedented resolution. However, the data generated by these arrays are several-fold larger than data from earlier platforms, creating a need for efficient analysis tools that scale robustly with data size. We developed a new aberration caller, Ultrasome, that delineates genomic changes-of-interest with dramatically improved efficiency. Ultrasome shows near-linear computational complexity and processes latest generation copy number arrays about 10,000 times faster than standard methods with preserved analytic accuracy.
Medical subject headings
- Chromosome Aberrations
- Computational Biology
- Oligonucleotide Array Sequence Analysis