Fluorescence enhancement by Au nanostructures: nanoshells and nanorods.
basic_science · Level V
Where this comes from
- Record sourced from PubMed, PMID 19231823.
- Also identified by DOI 10.1021/nn900001q.
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Abstract
Metallic nanoparticles influence the quantum yield and lifetime of adjacent fluorophores in a manner dependent on the properties of the nanostructure. Here we directly compare the fluorescence enhancement of the near-infrared fluorophore IR800 by Au nanoshells (NSs) and Au nanorods (NRs), where human serum albumin (HSA) serves as a spacer layer between the nanoparticle and the fluorophore. Our measurements reveal that the quantum yield of IR800 is enhanced from approximately 7% as an isolated fluorophore to 86% in a NSs-HSA-IR800 complex and 74% in a NRs-HSA-IR800 complex. This dramatic increase in fluorescence shows tremendous potential for contrast enhancement in fluorescence-based bioimaging.
Medical subject headings
- Biosensing Techniques
- Fluorescence
- Nanostructures