An interference localized surface plasmon resonance biosensor based on the photonic structure of Au nanoparticles and SiO2/Si multilayers.

Hiep, Ha Minh; Yoshikawa, Hiroyuki; Saito, Masato; Tamiya, Eiichi · ACS Nano · 2009

basic_science · Level V

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Abstract

This paper presents the experimental and simulation analysis of an original nanostructure design constructed with plasmonic gold nanoparticles and photonic thin-film multilayers of silicon dioxide (500 nm in thickness) and silicon on a substrate. Our nanostructure substrate showed a high sensitivity for various refractive index RI solutions and a prominent capacity for functionalizing alkanethiol molecules on the gold surface and demonstrates great potential in the development of a microfluidic-based biosensor for monitoring biotin-avidin interactions in real-time.

Medical subject headings