Evolution and functions of long noncoding RNAs.
review · Level V
Where this comes from
- Record sourced from PubMed, PMID 19239885.
- Also identified by DOI 10.1016/j.cell.2009.02.006.
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Abstract
RNA is not only a messenger operating between DNA and protein. Transcription of essentially the entire eukaryotic genome generates a myriad of non-protein-coding RNA species that show complex overlapping patterns of expression and regulation. Although long noncoding RNAs (lncRNAs) are among the least well-understood of these transcript species, they cannot all be dismissed as merely transcriptional "noise." Here, we review the evolution of lncRNAs and their roles in transcriptional regulation, epigenetic gene regulation, and disease.
Medical subject headings
- Evolution, Molecular
- Gene Expression Regulation
- RNA, Untranslated