Pre-mRNA processing reaches back to transcription and ahead to translation.
review · Level V
Where this comes from
- Record sourced from PubMed, PMID 19239889.
- Also identified by DOI 10.1016/j.cell.2009.02.001.
- No licence information is recorded for this record.
- Because redistribution is not established, this page shows the abstract only. Follow the links below for the full text.
Abstract
The pathway from gene activation in the nucleus to mRNA translation and decay at specific locations in the cytoplasm is both streamlined and highly interconnected. This review discusses how pre-mRNA processing, including 5' cap addition, splicing, and polyadenylation, contributes to both the efficiency and fidelity of gene expression. The connections of pre-mRNA processing to upstream events in transcription and downstream events, including translation and mRNA decay, are elaborate, extensive, and remarkably interwoven.
Medical subject headings
- Gene Expression Regulation
- Protein Biosynthesis
- RNA Precursors
- RNA Processing, Post-Transcriptional
- Transcription, Genetic