mRNA localization: gene expression in the spatial dimension.
review · Level V
Where this comes from
- Record sourced from PubMed, PMID 19239891.
- Also identified by DOI 10.1016/j.cell.2009.01.044 and PMC identifier 2819924.
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Abstract
The localization of mRNAs to subcellular compartments provides a mechanism for regulating gene expression with exquisite temporal and spatial control. Recent studies suggest that a large fraction of mRNAs localize to distinct cytoplasmic domains. In this Review, we focus on cis-acting RNA localization elements, RNA-binding proteins, and the assembly of mRNAs into granules that are transported by molecular motors along cytoskeletal elements to their final destination in the cell.
Medical subject headings
- RNA Transport
- RNA, Messenger