Regulation of translation initiation in eukaryotes: mechanisms and biological targets.
review · Level V
Where this comes from
- Record sourced from PubMed, PMID 19239892.
- Also identified by DOI 10.1016/j.cell.2009.01.042 and PMC identifier 3610329.
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Abstract
Translational control in eukaryotic cells is critical for gene regulation during nutrient deprivation and stress, development and differentiation, nervous system function, aging, and disease. We describe recent advances in our understanding of the molecular structures and biochemical functions of the translation initiation machinery and summarize key strategies that mediate general or gene-specific translational control, particularly in mammalian systems.
Medical subject headings
- Gene Expression Regulation
- Peptide Chain Initiation, Translational