Palettes of vaccines and immunostimulatory monoclonal antibodies for combination.
editorial · Level V
Where this comes from
- Record sourced from PubMed, PMID 19240168.
- Also identified by DOI 10.1158/1078-0432.CCR-08-2931 and PMC identifier 3653776.
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Abstract
Various monoclonal antibodies (mAb) target immune system molecules to enhance immunity by costimulating T cells (i.e., CD137, OX40, CD40, GITR) or interfering in coinhibitory signals (i.e., CTLA-4, PD-1). These powerful agents can be guided by cancer vaccines to enhance immunity against tumor but not self tissues. Clinically powerful therapeutic synergies are at hand.
Medical subject headings
- Antibodies, Monoclonal
- Cancer Vaccines
- Neoplasms