Emergence of ciprofloxacin-resistant Neisseria meningitidis in North America.
case_series · Level IV
Where this comes from
- Record sourced from PubMed, PMID 19246360.
- Also identified by DOI 10.1056/NEJMoa0806414.
- No licence information is recorded for this record.
- Because redistribution is not established, this page shows the abstract only. Follow the links below for the full text.
Abstract
We report on three cases of meningococcal disease caused by ciprofloxacin-resistant Neisseria meningitidis, one in North Dakota and two in Minnesota. The cases were caused by the same serogroup B strain. To assess local carriage of resistant N. meningitidis, we conducted a pharyngeal-carriage survey and isolated the resistant strain from one asymptomatic carrier. Sequencing of the gene encoding subunit A of DNA gyrase (gyrA) revealed a mutation associated with fluoroquinolone resistance and suggests that the resistance was acquired by means of horizontal gene transfer with the commensal N. lactamica. In susceptibility testing of invasive N. meningitidis isolates from the Active Bacterial Core surveillance system between January 2007 and January 2008, an additional ciprofloxacin-resistant isolate was found, in this case from California. Ciprofloxacin-resistant N. meningitidis has emerged in North America.
Medical subject headings
- Anti-Infective Agents
- Ciprofloxacin
- Drug Resistance, Bacterial
- Meningococcal Infections
- Neisseria meningitidis
- Point Mutation