MicroRNAs as novel regulators of angiogenesis.
review · Level V
Where this comes from
- Record sourced from PubMed, PMID 19246688.
- Also identified by DOI 10.1161/CIRCRESAHA.108.191270 and PMC identifier 2760389.
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Abstract
MicroRNAs are short noncoding RNAs that function as negative regulators of gene expression. Posttranscriptional regulation by miRNAs is important for many aspects of development, homeostasis, and disease. Endothelial cells are key regulators of different aspects of vascular biology, including the formation of new blood vessels (angiogenesis). Here, we review the approaches and current experimental evidence for the involvement of miRNAs in the regulation of the angiogenic process and their potential therapeutic applications for vascular diseases associated with abnormal angiogenesis.
Medical subject headings
- Angiogenic Proteins
- Endothelial Cells
- MicroRNAs
- Neovascularization, Physiologic