Renal damage in mice after sequential cisplatin and irradiation: the influence of prior irradiation on platinum elimination.
basic_science · Level V
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- Record sourced from PubMed, PMID 1924867.
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Abstract
Doses of 4-6 mg kg-1 c-DDP given 6 months before renal irradiation caused only a modest increase in functional radiation damage (DEF 1.1). These effects could be explained by additive toxicities and the damage was much less than when c-DDP was given 3-6 months after irradiation. Pharmacokinetic studies did not demonstrate any decrease in the rate of platinum elimination after previous low-dose renal irradiation.
Medical subject headings
- Cisplatin
- Kidney
- Platinum
- Radiation Injuries, Experimental