Neonatal alloimmune thrombocytopenia in Norway: poor detection rate with nonscreening versus a general screening programme.
cross_sectional · Level IV
Where this comes from
- Record sourced from PubMed, PMID 19250370.
- Also identified by DOI 10.1111/j.1471-0528.2008.02068.x.
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Abstract
The implementation of an antenatal screening programme for neonatal alloimmune thrombocytopenia (NAIT) is currently under debate. We evaluated the detection rate for NAIT in a nonscreened population of 661,200 births where NAIT was diagnosed on clinical indication. We did a cross-sectional comparison with a population of 100,448 human platelet antigen 1a (HPA1a)-screened pregnancies from three of the five health regions in Norway. In a nonscreening situation, 7.5 cases of NAIT were detected per year compared with 53 cases when screening was applied. The detection rate of NAIT in Norway was therefore 14% of the expected rate.
Medical subject headings
- Antigens, Human Platelet
- Prenatal Diagnosis
- Thrombocytopenia, Neonatal Alloimmune