Iron sensing as a partnership: HFE and transferrin receptor 2.
editorial · Level V
Where this comes from
- Record sourced from PubMed, PMID 19254564.
- Also identified by DOI 10.1016/j.cmet.2009.02.004.
- No licence information is recorded for this record.
- Because redistribution is not established, this page shows the abstract only. Follow the links below for the full text.
Abstract
The mechanism by which HFE participates in the regulation of iron homeostasis has remained enigmatic. Gao et al. (2009) make the key discovery that the regulation of hepcidin in response to holotransferrin requires the interaction between HFE and transferrin receptor 2 (TfR2).
Medical subject headings
- Histocompatibility Antigens Class I
- Iron
- Membrane Proteins
- Receptors, Transferrin