Insulin action under arrestin.
basic_science · Level V
Where this comes from
- Record sourced from PubMed, PMID 19254565.
- Also identified by DOI 10.1016/j.cmet.2009.02.005.
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Abstract
Insulin signaling is key to the etiology of metabolic syndrome. Recent work (Luan et al., 2009) uncovers a role for beta-arrestin, previously known to control GPCR desensitization, in insulin signaling. In mouse models, beta-arrestin-2 controls whole-body insulin action by regulating assembly of a complex containing insulin receptor, c-Src, and Akt.
Medical subject headings
- Arrestins
- Insulin
- Signal Transduction