SpliceAid: a database of experimental RNA target motifs bound by splicing proteins in humans.
basic_science · Level V
Where this comes from
- Record sourced from PubMed, PMID 19261717.
- Also identified by DOI 10.1093/bioinformatics/btp124.
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Abstract
The correct post-transcriptional RNA processing is finely regulated by RNA-binding proteins. Unfortunately, there is little experimental information on target RNA sequences of RNA-binding proteins and moreover such experimentally derived target sequences are annotated in a compact form by the score matrices that overestimate the number of possible recognized sequences. We carried out an exhaustive hand curated literature search to create a database, SpliceAid, collecting all the experimentally assessed target RNA sequences that are bound by splicing proteins in humans. We built a web resource, database driven, to easy query SpliceAid and give back the results by an accurate and dynamic graphic representation. SpliceAid database is freely accessible at http://www.introni.it/splicing.html.
Medical subject headings
- Databases, Nucleic Acid
- RNA
- RNA Splicing
- RNA-Binding Proteins