The challenge of finding a cure for HIV infection.
review · Level V
Where this comes from
- Record sourced from PubMed, PMID 19265012.
- Also identified by DOI 10.1126/science.1165706.
- No licence information is recorded for this record.
- Because redistribution is not established, this page shows the abstract only. Follow the links below for the full text.
Abstract
Although combination therapy for HIV infection represents a triumph for modern medicine, chronic suppressive therapy is required to contain persistent infection in reservoirs such as latently infected CD4+ lymphocytes and cells of the macrophage-monocyte lineage. Despite its success, chronic suppressive therapy is limited by its cost, the requirement of lifelong adherence, and the unknown effects of long-term treatment. This review discusses our current understanding of suppressive antiretroviral therapy, the latent viral reservoir, and the needs for and challenges of attacking this reservoir to achieve a cure.
Medical subject headings
- Anti-HIV Agents
- HIV
- HIV Infections
- Virus Latency