Peri-conceptional A1C and risk of serious adverse pregnancy outcome in 933 women with type 1 diabetes.
prospective_cohort · Level II
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- Record sourced from PubMed, PMID 19265024.
- Also identified by DOI 10.2337/dc08-2061 and PMC identifier 2681038.
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Abstract
To study the association between peri-conceptional A1C and serious adverse pregnancy outcome (congenital malformations and perinatal mortality). Prospective data were collected in 933 singleton pregnancies complicated by type 1 diabetes. The risk of serious adverse outcome at different A1C levels was compared with the background population. The risk was significantly higher when peri-conceptional A1C exceeded 6.9%, and the risk tended to increase gradually with increasing A1C. Women with A1C exceeding 10.4% had a very high risk of 16%. Congenital malformation rate increased significantly at A1C above 10.4%, whereas perinatal mortality was increased even at A1C below 6.9%. These results support recent guidelines of preconceptional A1C levels <7% in women with type 1 diabetes.
Medical subject headings
- Chromosome Aberrations
- Diabetes Mellitus, Type 1
- Glycated Hemoglobin
- Perinatal Mortality
- Pregnancy Complications
- Pregnancy Outcome