The side story of stem-like glioma cells.
editorial · Level V
Where this comes from
- Record sourced from PubMed, PMID 19265652.
- Also identified by DOI 10.1016/j.stem.2009.02.004.
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Abstract
In this issue of Cell Stem Stell, Bleau et al. report that activity of the drug transporter ABCG2 defines a tumorigenic stem-like side population (SP) isolated from glioma. Surprisingly, temozolomide, the first-line chemotherapeutic used for treatment of glioma, increased this side population, and even more so when PTEN was deleted.
Medical subject headings
- ATP-Binding Cassette Transporters
- Antineoplastic Agents, Alkylating
- Brain Neoplasms
- Dacarbazine
- Glioma
- Neoplasm Proteins
- Neoplastic Stem Cells