A STIMulus Package puts orai calcium channels to work.
basic_science · Level V
Where this comes from
- Record sourced from PubMed, PMID 19269360.
- Also identified by DOI 10.1016/j.cell.2009.02.022.
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Abstract
Activation of plasma membrane calcium channels by depletion of endoplasmic reticulum (ER) calcium stores is important for calcium entry in many cell types. Park et al. (2009) now show that direct binding of the ER protein STIM to tetramers of the Orai1 calcium channel in the plasma membrane triggers opening of this channel.
Medical subject headings
- Calcium Channels
- Membrane Proteins
- Neoplasm Proteins