PPTR-1 counterAkts insulin signaling.
basic_science · Level V
Where this comes from
- Record sourced from PubMed, PMID 19269361.
- Also identified by DOI 10.1016/j.cell.2009.02.029.
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Abstract
The serine/threonine kinase Akt is a focal point in signaling pathways that control cell tumorigenesis and insulin resistance. In this issue, Padmanabhan et al. (2009) identify a phosphatase regulatory subunit PPTR-1 that regulates the insulin/insulin-like growth factor 1 pathway by counteracting Akt activity in worms and mammalian cells.
Medical subject headings
- Caenorhabditis elegans
- Caenorhabditis elegans Proteins
- Insulin
- Proto-Oncogene Proteins c-akt
- Signal Transduction