TRIM-NHL proteins take on miRNA regulation.
basic_science · Level V
Where this comes from
- Record sourced from PubMed, PMID 19269362.
- Also identified by DOI 10.1016/j.cell.2009.02.030.
- No licence information is recorded for this record.
- Because redistribution is not established, this page shows the abstract only. Follow the links below for the full text.
Abstract
The TRIM-NHL family of proteins is conserved among metazoans and has been shown to regulate cell proliferation and development. In this issue, Hammell et al. (2009) and Schwamborn et al. (2009) identify two members of this protein family, NHL-2 in worms and TRIM32 in mice, as positive regulators of microRNA function.
Medical subject headings
- Basic Helix-Loop-Helix Proteins
- MicroRNAs
- Ubiquitin-Protein Ligases