Neonatal desensitization allows long-term survival of neural xenotransplants without immunosuppression.
basic_science · Level V
Where this comes from
- Record sourced from PubMed, PMID 19270699.
- Also identified by DOI 10.1038/nmeth.1308.
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Abstract
Preclinical development of human cells for potential therapeutic application in neurodegenerative diseases requires that their long-term survival, stability and functional efficacy be studied in animal models of human disease. Here we describe a strategy for long-term immune protection of human fetal and stem cell-derived neural cells transplanted into the adult rat brain, by desensitizing the host rat to similar cells in the neonatal period, without the need for additional immunosuppression.
Medical subject headings
- Brain
- Desensitization, Immunologic
- Graft Survival
- Neurons
- Stem Cell Transplantation