Multiwalled carbon nanotubes specifically inhibit osteoclast differentiation and function.
basic_science · Level V
Where this comes from
- Record sourced from PubMed, PMID 19284728.
- Also identified by DOI 10.1021/nl8030746.
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Abstract
Since attention has been paid to the use of multiwalled carbon nanotubes (MWCNTs) as biomaterials in contact with bone, it is critical to understand the reaction of bone cells to MWCNTs. We show that MWCNTs inhibit osteoclastic bone resorption in vivo and that MWCNTs inhibit osteoclastic differentiation and suppressed a transcription factor essential for osteoclastogenesis in vitro. These results suggest that MWCNTs have beneficial effects on bones when they are used as biomaterials.
Medical subject headings
- Cell Differentiation
- Nanotubes, Carbon
- Osteoclasts