Label-free DNA sensor based on surface charge modulated ionic conductance.
basic_science · Level V
Where this comes from
- Record sourced from PubMed, PMID 19284734.
- Also identified by DOI 10.1021/nn900113x and PMC identifier 2729444.
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Abstract
The surface charge effect in controlling ionic conductance through a nanoporous alumina membrane is investigated for its application in a convenient detection method of unlabeled DNA. To this goal, surface modification with mixtures of neutral silanes and morpholinos (neutral analogues of DNA) was optimized to yield a strong effect on ionic conductance change upon DNA binding, which can exceed an order of magnitude. The effect can be employed in fabrication of inexpensive DNA sensors.
Medical subject headings
- Biosensing Techniques
- DNA