Naloxone reversal of hypotension due to captopril overdose.
case_report · Level V
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- Record sourced from PubMed, PMID 1928887.
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Abstract
The hemodynamic effects of captopril and other angiotensin-converting enzyme inhibitors may be mediated by the endogenous opioid system. The opioid antagonist naloxone has been shown to block or reverse the hypotensive actions of captopril. We report a case of an intentional captopril overdose, manifested by marked hypotension, that resolved promptly with the administration of naloxone. To our knowledge, this is the first reported case of captopril-induced hypotension treated with naloxone. Our experience demonstrates a possible role of naloxone in the reversal of hypotension resulting from captopril.
Medical subject headings
- Captopril
- Hypotension
- Naloxone