Confinement spectroscopy: probing single DNA molecules with tapered nanochannels.
basic_science · Level V
Where this comes from
- Record sourced from PubMed, PMID 19290607.
- Also identified by DOI 10.1021/nl803030e.
- No licence information is recorded for this record.
- Because redistribution is not established, this page shows the abstract only. Follow the links below for the full text.
Abstract
We demonstrate a confinement spectroscopy technique capable of probing small conformational changes of unanchored single DNA molecules in a manner analogous to force spectroscopy, in the regime corresponding to femtonewton forces. In contrast to force spectroscopy, various structural forms of DNA can easily be probed, as indicated by experiments on linear and circular DNA. The extension of circular DNA is found to scale according to the de Gennes exponent, unlike for linear DNA.
Medical subject headings
- DNA
- DNA Probes
- Nanotechnology
- Spectrum Analysis