The treatable dementia of Sjögren's syndrome.

Caselli, R J; Scheithauer, B W; Bowles, C A; Trenerry, M R; Meyer, F B; Smigielski, J S; Rodriguez, M · Ann Neurol · 1991

case_report · Level V

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Abstract

Progressive dementia developed during a 15-month period in a 56-year-old woman with serologically and clinically documented primary Sjögren's syndrome. Findings from magnetic resonance imaging and angiography were normal, but a brain biopsy disclosed perivascular lymphocytic inflammation in leptomeningeal and parenchymal vessels. Treatment with high-dose corticosteroids produced rapid and nearly complete resolution of the dementia.

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