No sensory neuropathy during pyridoxine treatment in homocystinuria.

Mpofu, C; Alani, S M; Whitehouse, C; Fowler, B; Wraith, J E · Arch Dis Child · 1991

case_series · Level IV

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Abstract

Seventeen patients with cystathionine synthase deficiency homocystinuria were examined clinically and neurophysiologically for evidence of sensory neuropathy. All had received high dose pyridoxine (vitamin B-6) for many years. Absence of neurological disturbance in all cases suggests long term treatment with pyridoxine in the dosages used in homocystinuric patients is not harmful.

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