Review: Ischaemia-reperfusion injury in flap surgery.
review · Level V
Where this comes from
- Record sourced from PubMed, PMID 19299216.
- Also identified by DOI 10.1016/j.bjps.2009.01.060.
- No licence information is recorded for this record.
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Abstract
Ischaemia-reperfusion injury is the mechanism underlying (partial) flap loss. This is not only a traumatic event for the patient, it also causes increased patient morbidity [Kerrigan CL, Stotland MA. Ischemia reperfusion injury: a review. Microsurgery 1993;14:165-75] as well as prolonged hospitalisation, increasing medical consumption and costs. For surgeons who perform flap surgery, it is important to have knowledge of ischaemia-reperfusion injury in order to prevent it. In this article, an update on the recent research on ischaemia-reperfusion is given. The production of reactive oxygen species, neutrophil influx, depletion of NO and apoptosis are discussed as well.
Medical subject headings
- Reperfusion Injury
- Surgical Flaps