DISC1 partners with GSK3beta in neurogenesis.
basic_science · Level V
Where this comes from
- Record sourced from PubMed, PMID 19303839.
- Also identified by DOI 10.1016/j.cell.2009.03.005 and PMC identifier 6188698.
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Abstract
The protein DISC1, encoded by a gene implicated in schizophrenia susceptibility, regulates the development of postmitotic neurons. Mao et al. (2009) now report that DISC1 also regulates the proliferation of embryonic and adult neural progenitor cells through the GSK3beta/beta-catenin pathway, providing new insights into how susceptibility genes may contribute to the etiology of psychiatric disorders.
Medical subject headings
- Glycogen Synthase Kinase 3
- Nerve Tissue Proteins
- Neurogenesis