A MAPK scaffold lends a helping hand.
basic_science · Level V
Where this comes from
- Record sourced from PubMed, PMID 19303841.
- Also identified by DOI 10.1016/j.cell.2009.03.002.
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Abstract
The scaffold proteins of signaling pathways are thought to act as passive tethering devices bringing together catalytic components of signaling cascades. Good et al. (2009) now reveal that in the budding yeast the scaffold protein Ste5 acts as an allosteric activator of the mitogen-activated protein kinase Fus3, rendering it competent to be a kinase substrate for signal transmission.
Medical subject headings
- Adaptor Proteins, Signal Transducing
- Mitogen-Activated Protein Kinases
- Saccharomyces cerevisiae
- Saccharomyces cerevisiae Proteins