Rethinking ALS: the FUS about TDP-43.
review · Level V
Where this comes from
- Record sourced from PubMed, PMID 19303844.
- Also identified by DOI 10.1016/j.cell.2009.03.006 and PMC identifier 3110083.
- No licence information is recorded for this record.
- Because redistribution is not established, this page shows the abstract only. Follow the links below for the full text.
Abstract
Mutations in TDP-43, a DNA/RNA-binding protein, cause an inherited form of the neurodegenerative disease amyotrophic lateral sclerosis (ALS). Two recent studies (Kwiatkowski et al., 2009; Vance et al., 2009) now report that mutations in FUS/TLS, another DNA/RNA-binding protein, also trigger premature degeneration of motor neurons. TDP-43 and FUS/TLS have striking structural and functional similarities, implicating alterations in RNA processing as a key event in ALS pathogenesis.
Medical subject headings
- Amyotrophic Lateral Sclerosis
- DNA-Binding Proteins
- RNA-Binding Protein FUS