Intermittent active motion versus immobilization in the treatment of Staphylococcus aureus-induced arthritis in a rabbit model.
basic_science · Level V
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- Record sourced from PubMed, PMID 19308547.
- Also identified by DOI 10.1007/s11832-008-0128-7 and PMC identifier 2656873.
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Abstract
This study has evaluated the effects of immobilization versus intermittent active motion on cartilage and on antibiotic efficacy in a rabbit septic arthritis model. Rabbits were infected and assigned to one of four groups: group 1, no treatment without immobilization (allowing intermittent active motion); group 2, cast; group 3, oxacillin without immobilization; group 4, oxacillin and cast. Animals were sacrificed 21 days later. Bacterial counts and lateral radiograms were performed. A radiological score was calculated. Immobilization had no effect on oxacillin efficacy and a deleterious effect on the radiological score. Intermittent active motion has allowed a better cartilage healing during the treatment of septic arthritis.