Benzaldehyde-functionalized polymer vesicles.

Sun, Guorong; Fang, Huafeng; Cheng, Chong; Lu, Peng; Zhang, Ke; Walker, Amy V; Taylor, John-Stephen A; Wooley, Karen L · ACS Nano · 2009

basic_science · Level V

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Abstract

Polymer vesicles with diameters of ca. 100-600 nm and bearing benzaldehyde functionalities within the vesicular walls were constructed through self-assembly of an amphiphilic block copolymer PEO(45)-b-PVBA(26) in water. The reactivity of the benzaldehyde functionalities was verified by cross-linking the polymersomes and also by a one-pot cross-linking and functionalization approach to further render the vesicles fluorescent, each via reductive amination. In vitro studies found these labeled nanostructures to undergo cell association.

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