Long-term small molecule and protein elution from TiO2 nanotubes.
basic_science · Level V
Where this comes from
- Record sourced from PubMed, PMID 19323554.
- Also identified by DOI 10.1021/nl9001052.
- No licence information is recorded for this record.
- Because redistribution is not established, this page shows the abstract only. Follow the links below for the full text.
Abstract
In this study, TiO(2) nanotubes of various dimensions were used to elute albumin, a large protein molecule, as well as sirolimus and paclitaxel, common small molecule drugs. The nanotubes controlled small molecule diffusion for weeks and large molecule diffusion for a month. Drug eluted from the nanotubes was bioactive and decreased cell proliferation in vitro. Elution kinetics was most profoundly affected by tube height. This study demonstrates that TiO(2) nanotubes may be a promising candidate for a drug-eluting implant coating.
Medical subject headings
- Drug Implants
- Nanotubes
- Pharmaceutical Preparations
- Proteins
- Titanium