Zafirlukast (Accolate): A new treatment for capsular contracture.
case_series · Level IV
Where this comes from
- Record sourced from PubMed, PMID 19331987.
- Also identified by DOI 10.1067/maj.2002.126753.
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Abstract
Capsular contracture after breast augmentation or reconstructive breast surgery is a difficult problem. Previous studies have suggested that alteration of the inflammatory response could have a role in reducing the incidence of capsular contracture. We report a series of patients with Baker class III or IV capsular contracture who underwent treatment with zafirlukast. Patients received a regimen of zafirlukast 20 mg by mouth 2 times daily for 3 months. In many cases, dramatic softening of the breast capsule was evident after 1 to 3 months of treatment. Zafirlukast appears to effectively soften early capsular contracture and may prevent the formation of capsular contracture in those patients at risk. (Aesthetic Surg J 2002;22:329-336.).