Regulation of renal arteriolar tone by adenosine: novel role for type 2 receptors.
review · Level V
Where this comes from
- Record sourced from PubMed, PMID 19337216.
- Also identified by DOI 10.1038/ki.2009.18 and PMC identifier 5858198.
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Abstract
Tubuloglomerular feedback regulation of glomerular filtration rate (GFR) is mediated by adenosine, which acts on type 1 receptors in the afferent arteriole to increase resistance. However, new findings in isolated mouse tissue suggest that adenosine also dilates the efferent arteriole, which would reinforce the ability of adenosine to reduce GFR. This new information extends the concept that adenosine acts as a paracrine agent on both afferent and efferent arterioles.
Medical subject headings
- Adenosine
- Arterioles
- Feedback, Physiological
- Glomerular Filtration Rate
- Receptor, Adenosine A2A