Cardiovascular regeneration: pushing and pulling on progenitors.
editorial · Level V
Where this comes from
- Record sourced from PubMed, PMID 19341614.
- Also identified by DOI 10.1016/j.stem.2009.03.008.
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Abstract
In this issue of Cell Stem Cell, Zaruba et al. (2009) describe a pharmacoregenerative strategy for myocardial infarction. Using G-CSF to release progenitors from bone marrow and protease inhibition to prevent degradation of the homing signal, SDF-1, the authors achieve increased recruitment to the heart and improved heart function.
Medical subject headings
- Chemokine CXCL12
- Granulocyte Colony-Stimulating Factor
- Myocardial Infarction
- Neovascularization, Physiologic
- Receptors, CXCR4
- Regeneration