Fishing for a WNT-PGE2 link: beta-catenin is caught in the stem cell net-work.
basic_science · Level V
Where this comes from
- Record sourced from PubMed, PMID 19341616.
- Also identified by DOI 10.1016/j.stem.2009.03.006.
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Abstract
WNT and PGE2 signaling pathways are each associated with stem cell activity in the hematopoietic system. In a recent issue of Cell, Goessling et al. (2009) use the zebrafish model to reveal a conserved PKA-dependent mechanism that connects the two pathways via beta-catenin, enhancing stem cell proliferation and tissue regeneration.
Medical subject headings
- Dinoprostone
- Stem Cells
- Wnt Proteins
- Zebrafish
- Zebrafish Proteins
- beta Catenin