A wireless bio-MEMS sensor for C-reactive protein detection based on nanomechanics.
basic_science · Level V
Where this comes from
- Record sourced from PubMed, PMID 19342331.
- Also identified by DOI 10.1109/TBME.2008.2003262.
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Abstract
A quick wireless label-free detection of disease-related C-reactive proteins (CRPs) using a 200-microm-long microelectromechanical systems (MEMS) microcantilever housed in a 7 x 7 mm(2) reaction chamber with a safe reusable feature is reported. The assay time ranges from about 30 min to 3 h, depending on accuracy. The deflection of the microcantilever due to specific CRP-antiCRP binding is detected using a position-sensitive detector. The converted bio-signal is transmitted by a custom designed wireless amplitude-shift-keying (ASK) transceiver IC fabricated in a 0.18 microm CMOS process. CRP concentrations from 1 microg/mL to 500 microg/mL can be detected. A 0.2-Hz 1-V ac signal instead of traditional bases/acids is applied to the bio-MEMS sensor to unbind the CRP from the microcantilever for reusability.
Medical subject headings
- Biosensing Techniques
- C-Reactive Protein
- Micro-Electrical-Mechanical Systems
- Nanotechnology
- Signal Processing, Computer-Assisted