Tumour necrosis factor and cancer.
review · Level V
Where this comes from
- Record sourced from PubMed, PMID 19343034.
- Also identified by DOI 10.1038/nrc2628.
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Abstract
Tumour necrosis factor (TNF) is a major inflammatory cytokine that was first identified for its ability to induce rapid haemorrhagic necrosis of experimental cancers. When efforts to harness this anti-tumour activity in cancer treatments were underway, a paradoxical tumour-promoting role of TNF became apparent. Now that links between inflammation and cancer are appreciated, is TNF a target or a therapeutic in malignant disease -- or both?
Medical subject headings
- Neoplasms
- Tumor Necrosis Factor-alpha