Winter temperature and UV are tightly linked to genetic changes in the p53 tumor suppressor pathway in Eastern Asia.
Where this comes from
- Record sourced from PubMed, PMID 19344876.
- Also identified by DOI 10.1016/j.ajhg.2009.03.009 and PMC identifier 2667983.
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Abstract
The tumor suppressor p53 is a master sensor of stress. Two human-specific polymorphisms, p53 codon 72 and MDM2 SNP309, influence the activities of p53. There is a tight association between cold winter temperature and p53 Arg72 and between low UV intensity and MDM2 SNP309 G/G in a cohort of 4029 individuals across Eastern Asia that suggests causative selection. Moreover, the two polymorphisms are not coselected. Haplotype-based selection analysis further suggests that this is a striking example of two functional polymorphisms being strongly selected for in human populations in response to environmental stresses.
Medical subject headings
- Cold Climate
- Genes, p53
- Ultraviolet Rays