A Nurr1 pathway for neuroprotection.
basic_science · Level V
Where this comes from
- Record sourced from PubMed, PMID 19345183.
- Also identified by DOI 10.1016/j.cell.2009.03.024.
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Abstract
Mutations in the gene encoding the orphan nuclear receptor Nurr1 are linked to a rare familial form of Parkinson's disease. By examining the function of its mouse homolog, Saijo et al. (2009) provide evidence that Nurr1 protects dopaminergic neurons by suppressing inflammatory gene expression in astrocytes and microglia.
Medical subject headings
- DNA-Binding Proteins
- Parkinson Disease
- Transcription Factors