beta-tting on p63 as a metastatic suppressor.
basic_science · Level V
Where this comes from
- Record sourced from PubMed, PMID 19345184.
- Also identified by DOI 10.1016/j.cell.2009.03.028.
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Abstract
Although much is known about the genes that promote metastasis, few suppressors of metastasis have been found. Adorno et al. (2009) now identify p63 as a potent suppressor of metastasis and uncover an intricate mechanism for the inactivation of metastasis in cancer cells in response to transforming growth factor beta.
Medical subject headings
- Neoplasm Metastasis
- Trans-Activators
- Tumor Suppressor Proteins