The role of the mouse y chromosome on susceptibility to testicular germ cell tumors.
basic_science · Level V
Where this comes from
- Record sourced from PubMed, PMID 19351821.
- Also identified by DOI 10.1158/0008-5472.CAN-08-4881 and PMC identifier 3375048.
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Abstract
Testicular germ cell tumors (TGCT) are sex limited, occurring only in males with a Y chromosome. Recently, the gr/gr deletion on the human Y chromosome was associated with increased risk of TGCTs. In addition, the presence of Y chromosome sequences is associated with TGCTs in cases of gonadal dysgenesis. TGCTs in strain 129 males recapitulate many aspects of testicular cancer in human infants and can be used to evaluate the role of the Y chromosome in TGCT risk. We used chromosome substitution strains and a sex-reversing mutant to test the role of the Y chromosome on TGCT susceptibility. Our results show that a Y-linked gene that does not differ among the tested strains is essential for tumorigenesis.
Medical subject headings
- Neoplasms, Germ Cell and Embryonal
- Testicular Neoplasms
- Y Chromosome