Negative Smad expression and regulation in the developing chick limb.
basic_science · Level V
Where this comes from
- Record sourced from PubMed, PMID 19352514.
- Also identified by DOI 10.1371/journal.pone.0005173 and PMC identifier 2663054.
- Licence recorded as CC BY.
- The licence permits redistribution, so the abstract is shown in full and the full text is available from the publisher.
Abstract
The inhibitory or negative Smads, Smad6 and Smad7, block TGFbeta superfamily signals of both the BMP and TGFbeta classes by antagonizing the intracellular signal transduction machinery. We report the cloning of one Smad6 and two Smad7 (Smad7a and Smad7b) chick homologs and their expression and regulation in the developing limb. Smad6 and Smad7a are expressed in dynamic patterns reflecting the domains of BMP gene expression in the limb. Activation and inhibition of the BMP signaling pathway in limb mesenchyme indicates that negative Smad gene expression is regulated, at least in part, by BMP family signals.
Medical subject headings
- Extremities
- Gene Expression Regulation, Developmental
- Smad6 Protein
- Smad7 Protein