The insulin receptor talks to glucagon?
Level V
Where this comes from
- Record sourced from PubMed, PMID 19356709.
- Also identified by DOI 10.1016/j.cmet.2009.03.008.
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Abstract
Type 2 diabetes (T2DM) is not only a disorder of impaired insulin secretion but also glucagon oversecretion. However, the link between the two remains unclear. Is it possible that the latter is a consequence of the former? In this issue, Kawamori et al. (2009) have addressed this question by generating alpha cell-specific insulin receptor knockout mice.
Medical subject headings
- Glucagon
- Receptor, Insulin