Does statin usage reduce the risk of corticosteroid-related osteonecrosis in renal transplant population?
prospective_cohort · Level II
Where this comes from
- Record sourced from PubMed, PMID 19358908.
- Also identified by DOI 10.1016/j.ocl.2009.01.004 and PMC identifier 2801433.
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Abstract
The relationship between corticosteroids and osteonecrosis is well known. Limited data suggest that statins modulate cholesterol metabolism and may protect against osteonecrosis. The authors analyzed their prospective renal transplant database to determine if statin usage reduces the incidence of corticosteroid-related osteonecrosis and identified 2,881 renal transplantation patients who met the entry criteria. Among 338 patients on statins, 15 (4.4%) developed osteonecrosis, versus 180 of 2,543 (7%) patients who were not on statins. Osteonecrosis-free survival was similar in patients with and without statin exposure.
Medical subject headings
- Femur Head Necrosis
- Glucocorticoids
- Graft Rejection
- Hydroxymethylglutaryl-CoA Reductase Inhibitors
- Kidney Transplantation
Anatomy
- femur